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INHIBITORY EFFECT OF DEGRADED CARRAGEENAN ON THE FORMATION OF FASTING‐INDUCED AVILLOUS LESIONS IN THE GUINEA‐PIG DUODENUM
Author(s) -
Poulsen Steen Seier,
Fenger Claus
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb03586.x
Subject(s) - duodenum , guinea pig , carrageenan , chemistry , medicine , subcutaneous injection , inhibitory postsynaptic potential , endocrinology , biology , biochemistry
In response to total fasting guinea‐pigs develop avillous areas in the duodenum. It has been established that this reaction is due to the effect of acid gastric juice upon the duodenal mucosa. In the present study the acid production in some guinea‐pigs was inhibited by the subcutaneous administration of degraded carrageenan. It was demonstrated that this significantly reduced the formation of avillous areas in connection with fasting.