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THE FREQUENCY AND TOPOGRAPHICAL DISTRIBUTION OF CARCINOMA IN SITU WITH BUDS IN THE UTERINE CERVIX
Author(s) -
Rubio C. A.
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb03583.x
Subject(s) - carcinoma in situ , in situ , dysplasia , uterine cervix , carcinoma , lesion , pathology , medicine , anatomy , chemistry , organic chemistry
The frequency and distribution of carcinoma in situ with buds (CISB) in the cervical mucosa was studied in punch and/or cone specimens from 102 consecutive cases with dysplasia or carcinoma in situ. CISB was found in 20 per cent of the cases. Studies of the linear extension in sections of cone specimens showed that CISB represented a small portion (20 per cent) of the total atypical epithelium and only 33 per cent of the areas with carcinoma in situ, the remaining being carcinoma in situ simplex (CISS). In 6 of the 10 cones with CISB, the lesion was limited to only 1 of the 4 quadrants. Patients with dysplasia were on the average 5.4 years younger than those with carcinoma in situ. No differences in age were found for cases classified as carcinoma in situ with or without buds. The histological findings and age distribution indicate that CISB and CISS are histological variants of carcinoma in situ. There is no evidence that CISS progresses to CISB.