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INTERFERON PRODUCTION AND PREVENTION OF VIRAL INFECTIONS IN MICE BY COMPONENTS OF A MIXED BACTERIAL VACCINE
Author(s) -
Degré Miklos,
Dahl Helen
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1974.tb02390.x
Subject(s) - microbiology and biotechnology , vesicular stomatitis virus , virology , staphylococcus aureus , haemophilus influenzae , biology , enterobacter aerogenes , virus , interferon , bacteria , antibiotics , escherichia coli , biochemistry , genetics , gene
The bacterial components of the mixed standard bacterial vaccine (SBV) were tested for protective effect against influenza A 2 and Vesicular stomatitis virus (VSV) infection in mice, as measured by mortality and survival time. Klebsiella aerogenes and Haemophilus influenzae protected against both vira, Staphylococcus aureus against VSV and Neisseriae against influenza virus. Following injection of Klebsiella aerogenes, Haemophilus influenzae and Staphylococcus aureus significant titres of interferon (IF) could be detected in the serum. Correlation between protective effect and IF production was not complete, which may indicate that other host defence mechanism(s) are also activated by the vaccine components.