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UPTAKE OF STAPHYLOCOCCAL PROTEIN A BY PERITONEAL MACROPHAGES IN VITRO
Author(s) -
Heczko Piotr B.,
Grov .Arne,
Oeding Per
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1974.tb02324.x
Subject(s) - immune system , in vitro , guinea pig , macrophage , peritoneum , protein a , immunology , delayed hypersensitivity , microbiology and biotechnology , chemistry , biology , antibody , biochemistry , endocrinology , anatomy
Radioactive protein A is actively taken up by rabbit peritoneal macrophages in the presence of immune rabbit IgG, most probably due to an immune reaction leaving the Fc sites available for macrophage adherence. The low rate of protein A uptake by guinea pig peritoneal macrophages in the presence of normal or immune guinea pig sera is apparently a result of the extensive Fc‐interaction with protein A of the IgG in these sera. Delayed hypersensitivity to protein A of the donor animals does not influence the rate of uptake.