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CORRELATION OF PHYTOHAEMAGGLUTININ‐INDUCED LYMPHOCYTE TRANSFORMATION WITH CLINICAL MANIFESTATIONS OF SARCOIDOSIS *
Author(s) -
Horsmnhemo Maija,
Virolainen M.
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1974.tb02302.x
Subject(s) - phytohaemagglutinin , sarcoidosis , medicine , erythema nodosum , lymphocyte , immunology , dlco , pathology , dermatology , lung , lung function , disease , diffusing capacity
In vitro lymphocyte activation by phytohaemagglutinin was measured as 3 H‐TdR incorporation by buffy coat cultures from 90 patients with sarcoidosis. Neither the median response nor the geometric mean response in sarcoidosis differed significantly from those in controls. However, when the series was divided into clinical subgroups, patients with hilar adenopathy and parenchymal pulmonary changes had significantly weaker responses. The PHA response was significantly higher in patients with erythema nodosum than in those without this symptom.