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RENIN INACTIVATION IN VITRO IN PREGNANT AND POST PARTUM RABBIT UTERINE AND KIDNEY TISSUE
Author(s) -
Jørgensen Jørgen
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb00403.x
Subject(s) - post partum , uterus , renin–angiotensin system , kidney , incubation , in vitro , rabbit (cipher) , endocrinology , endogeny , medicine , chemistry , andrology , biology , pregnancy , biochemistry , blood pressure , genetics , statistics , mathematics
In slices of pregnant and post partum rabbit uterus 80 per cent of the endogenous renin was gradually inactivated during incubation in vitro at 37°C for 44 hours. In slices of rabbit kidney only 30 per cent was inactivated. Contrary to this there was only a slight, inconsistent, decrease in renin content in similarly incubated homogenates and extracts of uterine and renal tissue. The results show that intact tissue from both the kidney and especially the uterus have a capacity for inactivation of renin.