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LOCALIZATION OF IMMUNOGLOBULINS IN URINARY BLADDER TUMOURS
Author(s) -
Johansson Bengt,
Ljungqvist Arne
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb00386.x
Subject(s) - urinary bladder , urinary system , malignancy , pathology , antibody , medicine , urine , immunofluorescence , biopsy , urology , radial immunodiffusion , grading (engineering) , biology , immunology , ecology
Biopsy specimens from primary tumours of the urinary bladder in 36 patients were examined for the presence of immunoglobulins, using a direct immunofluorescence technique. The tumours were also studied by normal histological methods to determine the malignancy grade and degree of invasive growth as well as the presence of lymphocytes and plasma cells. An immunoglobulin estimation in urine and serum from the patients was performed by immunodiffusion. The IgM demonstrated in lymphocytes and plasma cells of the tumours' connective tissue stroma was found to be directly related to the malignancy grading. There was even a correlation to the urinary output of zgM, but not to its serum concentration. These results further support the view that an immune reaction occurs in epithelial tumours of the urinary bladder, and that an estimation of the urinary output of IgM can be of diagnostic value in these cases.