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EXTRAMEDULLARY HAEMOPOIESIS AND METASTASES IN THE SPLEEN
Author(s) -
Berge Thorbjörn
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb00380.x
Subject(s) - medicine , spleen , bone marrow , haematopoiesis , metastasis , pathology , surgery , cancer , stem cell , biology , genetics
Among 284 cases of haematogenous splenic metastases, haemopoiesis was demonstrated in the spleen in 38.0 per cent. Blood formation was found in 17.4 per cent of the cases without, and in 47.9 per cent of the cases with skeletal metastases (p<0.001). Among the cases with skeletal metastases, extramedullary blood formation was demonstrated in 68.7 per cent of those presenting involvement of all the vertebral bodies compared with 25.8 per cent of the remainder (p<0.001). The latter frequency (25.8 per cent) did not differ significantly from that (17.4 per cent) found among cases without skeletal metastases. The occurrence of skeletal metastases therefore appears to be of little importance in cases without extensive destruction of the bone marrow. Among cases with metastases in all the vertebral bodies, the frequency of extramedullary blood formation did not vary significantly with the type of metastases. Among other cases with or without skeletal metastases, extramedullary blood formation was more common among cases with sinusoidal metastases. This finding must, however, be judged with caution.