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ON THE INFLUENCE OF EXOGENEOUS CYCLIC AMP (3′, 5′‐ADENOSINE MONOPHOSPHATE) ON AMYLOID FORMATION IN CASEIN‐TREATED C 3 H MICE
Author(s) -
Ebbesen P.
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb00373.x
Subject(s) - theophylline , phosphodiesterase , medicine , adenosine , endocrinology , cyclic adenosine monophosphate , chemistry , intracellular , amyloid (mycology) , phosphodiesterase inhibitor , ibmx , adenosine monophosphate , receptor , biochemistry , enzyme , biology , inorganic chemistry , forskolin
Amyloid formation in caseinated C 3 H mice is enhanced by the administration of dibutyryl cyclic AMP (3′, 5,‐adenosine monophosphate), by the phosphodiesterase inhibitor theophylline and by combination of these two compounds. One beta receptor stimulator, soterenol, also enhanced amyloid development, but several other α and β receptor active substances tested were without effect in the dose used. It is hypothesized that a sustained elevation of intracellular cyclic‐AMP level can make cells produce amyloid.