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MCG101‐AA, A NEW ASCITES TUMOUR IN C 57 MICE
Author(s) -
Hagmar Björn
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb00361.x
Subject(s) - ascites , cell , pathology , neoplasm , cancer research , lung , biology , chemistry , medicine , biochemistry
The transplantability of a newly induced ascites tumour, MCG101‐AA, was compared with that of the solid tumour of origin, MCG101‐SS, and the ascites tumour in solid form, MCG101‐AS. The AA and AS tumours required lower cell inocula for growth i.p. than s.c., while SS had a similar transplantability at these two sites. If injected i.v., all tumours gave rise to extensive lung tumours. In addition, the SS tumour formed numerous extrapulmonary tumour takes, more than AS and AA, the latter giving rise only to a few such tumours. The evaluation of the results is complicated by different survival times after injection of the three tumours. But it is suggested that the dissemination pattern was altered by ascites transformation of the tumour. Possible mechanisms involved, such as cell surface alterations, are discussed.