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INFLUENCE OF CYCLOPHOSPHAMIDE TREATMENT AND NEONATAL THYMECTOMY ON GLOMERULAR CHANGES IN RATS WITH LONG‐TERM ALLOXAN DIABETES
Author(s) -
Hägg Erik
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb00359.x
Subject(s) - cyclophosphamide , glomerular basement membrane , medicine , endocrinology , alloxan , diabetes mellitus , diuresis , thymectomy , basement membrane , kidney , glomerulonephritis , chemotherapy , pathology , myasthenia gravis
The effect of cyclophosphamide treatment and neonatal thymectomy on glomerular lesions in rats with long‐term alloxan diabetes was studied. There were no significant differences between treated and untreated diabetic rats in the occurrence of glomerular IgG, graded and measured basement membrane thickness, and mesangial area. In cyclophosphamide treated animals, however, there was a tendency toward reduced thickening of the glomerular basement membrane without decrease of glomerular IgG and of the degree of diabetes, as measured by diuresis. The results do not support the assumption that immunological mechanisms are important in the pathogenesis of glomerular disease in diabetes.