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REPRESSION OF HYALURONIDASE IN STREPTOCOCCUS MITIS , ATCC 903
Author(s) -
Linder L.,
Sund M.L.
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1974.tb00229.x
Subject(s) - psychological repression , hyaluronidase , fructose , sucrose , mannose , galactose , enzyme , biochemistry , enzyme repression , carbohydrate , chemistry , biology , gene expression , gene
The synthesis of hyaluronidase, which is a constitutive, cell‐bound enzyme in Streptococcus mitis ATCC 903, was investigated in cultures grown on different carbohydrates. Mannose was found to repress enzyme synthesis completely. The repressive effect of glucose was concentration dependent. After a period of complete repression for less than one generation, the rate of synthesis increased rapidly in 0.06 M glucose while complete repression continued in 0.17 M glucose. Sucrose, fructose and galactose repressed enzyme synthesis only to a limited extent. Of all carbohydrates tested sucrose had the least repressive effect and supported a maximal rate of growth. Cyclic AMP partially relieved glucose repression, particularly in media of low glucose concentration. The same effect was, however, also obtained with 5′ AMP. Theophylline did not increase the effect of cyclic AMP in counteracting glucose repression. Cyclic AMP caused 30–50 per cent inhibition of the synthesis of hyaluronidase in non‐growing cells.