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EXPERIMENTAL CARDIAC HYPERTROPHY
Author(s) -
Unge Gunnar
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb03574.x
Subject(s) - ventricle , muscle hypertrophy , myocyte , uridine , medicine , labelling , cardiac hypertrophy , electron microscope , endothelium , chemistry , mitochondrion , myofibril , cardiac muscle , endocrinology , cardiology , anatomy , biology , rna , biochemistry , physics , optics , gene
Various forms of experimental cardiac hypertrophy were investigated by light and electron microscope autoradiography and measurements of myocardial tissue radioactivity after in vivo injections of 3 H‐5‐uridine in rats. In the autoradiograms, the degree of labelling of striated muscle cells and capillary wall cells was estimated. A significant increase in 3H‐5‐uridine incorporation was recorded in the striated muscle cells of the left ventricle wall of rats with aortic stenosis, hypertension of short duration and of swimming exercised rats. In the latter case, an increased labelling was recorded also in the myocardial capillary endothelium. In the hypertrophying heart, the uridine was found in the striated muscle cell mitochondria in higher percentage than in the controls.