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THE EFFECT ON RENAL HYPERTENSION OF SUBCUTANEOUS ISOTRANSPLANTATION OF RENAL MEDULLA FROM NORMAL OR HYPERTENSIVE RATS
Author(s) -
Manthorpe Tove
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb03565.x
Subject(s) - blood pressure , medicine , transplantation , renal medulla , medulla , kidney , endocrinology , depression (economics) , kidney transplantation , economics , macroeconomics
Following subcutaneous transplantation of normal renal medulla to renal hypertensive rats there was a long‐lasting depression of the blood pressure. There was no further depression after a second transplantation. Transplantation of medulla from the ischemic kidney of renal hypertensive donors, produced a similar depression of the blood pressure, whereas medulla from the untouched kidney had little effect. Subcutaneous implantation of gelatine sponge, sham operation and transplantation of normal renal cortex all produced only short‐lasting depressions of the blood pressure. Blood pressure measured in the afternoon was significantly lower than in the morning, both in normal and in renal hypertensive rats. The higher the blood pressure level, the more marked was this absolute difference.