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ORAL GIANT CELL GRANULOMAS: An Enzyme Histochemical and Ultrastructural Study
Author(s) -
Andersen L.,
Arwill T.,
Fejerskov O.,
Heyden G.,
Philipsen H. P.
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb03552.x
Subject(s) - giant cell , ultrastructure , acid phosphatase , diaphorase , succinate dehydrogenase , biology , stromal cell , cell , enzyme , aminopeptidase , dehydrogenase , biochemistry , chemistry , pathology , anatomy , leucine , genetics , amino acid , cancer research , medicine
Oral giant cell granulomas (8 peripheral and 4 central) have been studied histochemically for NADH 2 ‐diaphorase, NADPH 2 ‐diaphorase, glucose‐6‐phosphate dehydrogenase, glutamate dehydrogenase, adenosine triphosphatase, leucine aminopeptidase, and acid phosphatase activity. No differences in cellular enzyme activity are found between the peripheral and the central variety. The giant cells are positive for all the enzymes studied, except adenosine triphosphatase, whereas the pericytes of the vascular granulation tissue are positive for all the enzymes tested. 8 peripheral and 2 central oral giant cell granulomas have been studied electron microscopically. The ultrastructure of the two varieties is similar, both showing two different types of giant cells. Clusters of stromal cells, probably pericytes, are often found, lying in intimate relation with a distance of 150–140 Å between their cell membranes. Though no membrane fusions have been clearly demonstrated the histochemical activities of the giant cells and the pericytes lend support to the assumption, that the pericytes are precursors to the giant cells.