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THE PANCREATIC ISLET CELLS IN INSULAR AMYLOIDOSIS IN HUMAN DIABETIC AND NON‐DIABETIC ADULTS
Author(s) -
Westermark Per,
Grimelius Lars
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb03538.x
Subject(s) - islet , diabetes mellitus , amyloidosis , medicine , endocrinology , amyloid (mycology) , cell , beta cell , correlation , autopsy , pancreas , chemistry , pathology , biochemistry , geometry , mathematics
The relative pancreatic islet cell frequencies were studied in an autopsy material of diabetic and non‐diabetic 60‐year‐old and older persons with and without islet amyloidosis. The diabetics showed a slightly higher α 1 cell frequency, a higher α 2 cell frequency and a lower β cell frequency than the non‐diabetics. There was a positive correlation between the α 2 cell frequency and the percentage number of islets with amyloid deposits, and a negative correlation between the β cell frequency and this percentage number; the same applied when the effect of diabetes was eliminated by partial correlation analysis. The ratio between the nuclear sizes of the β and α 2 cells was fairly constant, even in cases with heavy islet amyloidosis where these sizes were decreased. Changes in size of the nuclei were therefore of no importance to the differential counts.