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EFFECT OF STANDARD BACTERIAL VACCINE ON INFLUENZA VIRUS INFECTION AND INTERFERON PRODUCTION IN GERMFREE MICE
Author(s) -
Degré Miklos,
Midtvedt Tore
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1973.tb02277.x
Subject(s) - biology , virus , interferon , virology , microbiology and biotechnology , viral infection , orthomyxoviridae , influenza a virus , immunology
A standard bacterial vaccine (SBV) induced interferon (IF) production and reduced the mortality due to influenza A 2 virus infection in germfree mice. These effects were quantitatively comparable in conventional and germfree mice. The length of survival was somewhat shorter in conventional mice. It is concluded, that SBV exerts a direct effect on the viral infection probably partly mediated by IF induction. The role of resident bacterial flora is discussed.