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SENSITIVITY TO NORMAL BRAIN ANTIGENS OF BLOOD LYMPHOCYTES FROM PATIENTS WITH GLIOMAS
Author(s) -
Wahlström T.
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1973.tb02273.x
Subject(s) - antigen , malignancy , immunology , medicine , in vitro , brain tissue , lymphocyte , lymphocyte activation , immunity , glioma , pathology , immune system , cancer research , chemistry , t cell , biochemistry
Immunological sensitivity to normal brain antigens of blood lymphocytes from neurosurgical patients and healthy subjects was investigated in vitro. Lymphocytes from 9 out of 14 patients with gliomas of varying histological malignancy were stimulated into enhanced DNA synthesis by two soluble extracts of brain tissue. Lymphocytes from one patient with brain infarction were also slightly stimulated. The mechanisms by which such immunity may be induced are discussed.