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OCCURRENCE OF OCHRATOXIN A AND CITRININ IN CEREALS ASSOCIATED WITH MYCOTOXIC PORCINE NEPHROPATHY
Author(s) -
Krogh P.,
Hald Benedicte,
Pedersen E. Jonas
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1973.tb02261.x
Subject(s) - citrinin , ochratoxin a , mycotoxin , ochratoxin , nephrotoxicity , chemistry , food science , toxicity , organic chemistry
A survey of the nephrotoxic mycotoxins ochratoxin and citrinin in cereals used as feed for bacon pigs was conducted, employing thin‐layer chromatography techniques, in districts of Denmark where the incidence rate of mycotoxic porcine nephropathy was high. A total of 58 per cent of the samples contained ochratoxin A and 9 per cent contained citrinin, always together with ochratoxin A. The detection of the two mycotoxins was confirmed by derivative formation and, for selected samples, by nuclear magnetic resonance spectroscopy (NMR). The maximal concentration of ochratoxin A and citrinin was 27.5 ppm and 2 ppm, respectively. About half of the contaminated samples contained more than 200 ppb, which is the level at which development of porcine nephropathy is possible. This is the first report which elucidates the association of ochratoxin A and citrinin and a naturally occurring disease in domestic animals.