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THE POTENCY OF BCG VACCINE DETERMINED BY THE TUBERCULIN SHOCK METHOD ON HAMSTERS
Author(s) -
Jespersen Andr.
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1973.tb02212.x
Subject(s) - potency , tuberculin , medicine , hamster , bcg vaccine , immunology , vaccination , virology , in vitro , biology , tuberculosis , pathology , biochemistry
BCG vaccinated hamsters, in contrast to non‐vaccinated, have been shown to be sensitive to tuberculin injected intraperitoneally. An introductory study showed that hamsters vaccinated with a strongly potent BCG strain were killed by tuberculin shock using about the same dose of purified tuberculin as in experiments on guinea pigs. In the main experiment, hamsters were vaccinated with vaccines prepared from BCG strains of weak, medium or strong potency, and injected with a large dose of tuberculin. It was demonstrated that the number of animals that died of shock was significantly different in the groups vaccinated with the three vaccines. Thus this method can be used for determination of the potency of a vaccine. The strains examined originated from the Danish strain of BCG received from Paris in 1931.