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ELECTRON MICROSCOPIC OBSERVATIONS ON FRACTURE REPAIR IN THE RAT
Author(s) -
Göthlin Gustav
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb00498.x
Subject(s) - callus , matrix (chemical analysis) , chemistry , bone matrix , electron microscope , femur , anatomy , microbiology and biotechnology , pathology , biophysics , biology , cartilage , botany , medicine , physics , paleontology , chromatography , optics
The morphology of the different cell types in “primary” callus obtained by fracturing the femur shaft of rats is described in this investigation which is based on electron microscopic observations of undemineralized callus tissue obtained at various intervals after fracturing. The different cell types could be divided into two main groups, one consisting of cells with predominant matrix manufacturing properties, and one with phagocytic (or matrix resorbing) function. Macrophages were not only present during early callus formation but were also observed in the callus until the late mineralized stages and may be of importance for remodeling of the tissue at the late intervals. Large electron dense mitochondrial granules were found in chondrocytes, osteoblasts, osteocytes, and osteoclasts located close to calcified matrix.