Premium
THE SPECIFICITY OF THE CHROMOSOMAL ABNORMALITIES IN HUMAN COLONIC POLYPS:
Author(s) -
Mark Joachim,
Mitelman Felix,
Dencker Hans,
Norryd Claes,
Tranberg KarlGöRAN
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb00481.x
Subject(s) - grading (engineering) , ploidy , chromosome , biology , pathology , genetics , medicine , gene , ecology
The chromosomes were studied in 7 polyps of the large bowel in a case of Gardner's syndrome. All tumours were histologically non‐invasive. Four polyps had a normal diploid stemline and showed a predominantly hyperdiploid chromosome variation. Three polyps had heteroploid stemlines: two were pseudodiploid and one was hyperdiploid. The chromosomal difference between polyps of different size was merely quantitative. The same non‐random karyotypic pattern was found in all polyps irrespective of size and histological grading.