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ALLOXAN DIABETES IN DUCT‐LIGATED RATS:
Author(s) -
Edström Curt,
Boquist Lennart
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb00475.x
Subject(s) - alloxan , islet , endocrinology , parenchyma , diabetes mellitus , duct (anatomy) , medicine , pancreatic duct , chemistry , granulation tissue , pancreas , pathology , immunology , wound healing
The course of alloxan diabetes was studied ultrastructurally during 19 months in duct‐ligated and control rats. During the first days after alloxan administration, selective degeneration was observed in most β‐cells of both atrophic and intact pancreatic parenchyma. New formation of islet cells was found from about one week. Two different kinds of cells without characteristic granulation were seen: those which seemed to be precursor cells to granulated islet cells, and those which appeared to represent hypertrophic, de‐granulated β‐cells. The number of α 2 ‐cells was increased during the first months after the injection of alloxan. At 19 months a normal fine structure was found in the islets.