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ON ENZYME HISTOCHEMISTRY OF SARCOIDOSIS
Author(s) -
Palva T.,
Dammert K.,
Palva A.
Publication year - 1973
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1973.tb00011.x
Subject(s) - esterase , acid phosphatase , lymphatic system , lactate dehydrogenase , alkaline phosphatase , malate dehydrogenase , sarcoidosis , 5' nucleotidase , glutamate dehydrogenase , biology , enzyme , chemistry , biochemistry , microbiology and biotechnology , pathology , immunology , glutamate receptor , medicine , receptor
Hydrolase and oxidoreductase activity in mediastinal sarcoid lymph nodes of 20 patients was studied. Alkaline phosphatase activity was concentrated in the fibrous periphery of the tubercles, the lymphatic pulp and capillary walls. Strong acid phosphatase and moderate non‐specific esterase activity was seen in the tubercles, particularly in the nuclei of epithelioid cells and giant cells. Moderate adenosin triphosphatase and 5‐nucleotidase activity appeared in the tubercles as well as in the lymphatic pulp. Leucinaminopeptidase activity was weak and unregular. Strong activity of both lactate and malate dehydrogenase was found in the tubercles as well as in the lymphatic pulp, whereas glutamate dehydrogenase activity was weak. A tubercular rather than a viral aetiology is favoured.