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AMYLOIDOSIS IN MINK INDUCED BY REPEATED INJECTIONS OF ENDOTOXIN
Author(s) -
Nordstoga Knut
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb02160.x
Subject(s) - mink , amyloidosis , spleen , plasmacytosis , mononuclear phagocyte system , amyloid (mycology) , pathology , biology , immunology , medicine , ecology , multiple myeloma
Prolonged application of endotoxin derived from Escherichia coli led to deposits of amyloid in the spleen and liver in two different genotypes of mink. Simultaneous occurrence of infectious mink plasmacytosis did not seem to influence the response to endotoxin. An evident increase in PAS‐positive reticular cells, situated in close proximity to the amyloid storage, was demonstrated in the liver. Such cells were also found in the border zones of amyloid deposits in the spleen, in some cases. The results of this study suggest that the amyloid material was produced by “overstimulated” or dysfunctional reticuloendothelial cells.