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ON THE INFLUENCE OF NEURAMINIDASE ON CASEIN‐INDUCED AMYLOIDOSIS IN C 3 H MICE
Author(s) -
Ebbesen P.
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00358.x
Subject(s) - neuraminidase , spleen , amyloidosis , lymph node , chemistry , amyloid (mycology) , intraperitoneal injection , casein , enzyme , biochemistry , endocrinology , pathology , biology , immunology , medicine , inorganic chemistry
Intraperitoneal inoculation of the receptor‐destroying enzyme neuraminidase had little effect on spleen amyloid development in mice during caseination. However, incubation of normal syngeneic lymph node cells with neuraminidase before they were injected into mice during casein treatment significantly enhanced the amyloid‐promoting effect of the cells. It is suggested that neuraminidase‐treated lymph node cells may be preferentially trapped in the spleen with subsequent transfer of an amyloid component to macrophages. The polycation DEAE‐dextran, known to accelerate amyloid formation if given intraperitoneally with casein, did not influence the effect of cell transfer. This may indicate that the amyloid promoting mechanisms of the two membrane‐active substances are different.