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THE DIURNAL VARIATION OF THE FIRST MITOTIC WAVE RELEASED AMONG RAT KIDNEY TUBULE CELLS BY PARTIAL NEPHRECTOMY
Author(s) -
Saetren Hans
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00344.x
Subject(s) - mitosis , nephrectomy , kidney , noon , diurnal temperature variation , resection , biology , medicine , endocrinology , physics , surgery , microbiology and biotechnology , meteorology , atmospheric sciences
Mitotic waves were released in kidney tubules by resecting one kidney and a half in a group of 4 rats at intervals of a few hours during the 24‐hr‐cycle. The course of the mitotic wave appearing on the second day after the operation was followed in each half‐kidney by determining the incidence of mitosis at intervals of 3 hours. The waves showed a distinct diurnal pattern of variation: those initiated by resection between noon and midnight had single peaks, while those initiated by resection between 3 a.m. and 9 a.m. gave waves with 2 peaks. It is assumed that the single as well as the paired waves are based mainly on mitoses in the proximal tubules. The alternation between sequences of single‐ and double‐peaked waves through the 24 hours is interpreted as the result of an interference of an endogenous mitotic rhythm, the mitotic wave starting slightly less than 30 hr after the resection.