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RELATION BETWEEN RENIN SUBSTRATE AND ACUTE PHASE PROTEINS
Author(s) -
Bing Jens
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00329.x
Subject(s) - excretion , substrate (aquarium) , medicine , endocrinology , urine , renin–angiotensin system , chemistry , urinary system , biology , blood pressure , ecology
In adrenalectomized rats, renin substrate was, as previously found, extremely low in non‐substituted animals, markedly decreased in salt‐ substituted animals, but only slightly decreased in both salt‐ and DOCA‐substituted animals. After three of four injuries, known to increase acute phase proteins, there was also an adrenal‐dependent increase in renin substrate. A similar adrenal‐dependent increase in substrate was further found in 24‐hour uninephrectomized rats and in rats with ceased urine excretion, while the increase after binephrectomy is non‐adrenal‐dependent and thus not due to ceased urine excretion.