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RELEASE OF ANTIGEN‐BINDING CELLS FROM THE SPLEEN INTO THE BLOOD
Author(s) -
Sandberg Göran
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00307.x
Subject(s) - spleen , immune system , antigen , immunology , booster dose , medicine , peripheral blood , biology , immunization
The splenic release of lymphocytes specifically engaged in an immune response was quantitated in guinea pigs during a secondary response to sheep red blood cells (SRBC). The number of cells forming rosettes with SRBC was compared in splenic venous and arterial blood. The splenic veno‐arterial difference in the number of rosette‐forming cells (RFC) was compared in normal guinea pigs and at different intervals after a booster dose of SRBC, given 3 weeks after a primary dose. In normal guinea pigs there was no release of RFC from the spleen. A small release was found 3 weeks after a primary dose of SRBC. After a booster dose the splenic veno‐arterial difference in the number of RFC increased to a maximal value after 6 days. Simultaneously, the number of RFC was increasing in both the spleen and the blood. The results clearly indicate that the spleen releases lymphocytes with specific antigen receptors during the secondary immune response to SRBC.