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STUDIES ON CASEIN‐INDUCED AMYLOIDOSIS IN MICE WITH CONGENITAL APLASIA OF THE THYMUS
Author(s) -
Hardt F.,
Claësson M. H.
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00306.x
Subject(s) - amyloidosis , casein , aplasia , medicine , nude mouse , stimulation , ratón , pathology , endocrinology , biology , immunology , biochemistry , cancer
The mouse mutant nude suffers a congenital aplasia of the thymus, which results in a nearly total lack of thymus dependent lymphoid cells. In spite hereof amyloidosis was induced in nude mice with prolonged casein stimulation. The development of amyloidosis exhibited the usual pattern of distribution, but the induction time was significantly shorter in nude mice than in normal littermates. No circulating casein‐antibodies were found in nude mice during the development of amyloidosis. The possible role of tolerance as a pathogenetic mechanism in amyloidosis is discussed.