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STUDIES ON THE IN VIVO EFFECT OF POKE WEED MITOGEN (PWM) ON THE LYMPHOID TISSUE OF THE RAT
Author(s) -
Jørgensen Hans Paulli,
Jensen Mogens Krogh,
Olsen Jens Erland
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00292.x
Subject(s) - spleen , in vivo , bone marrow , lymphatic system , red pulp , lymph , peripheral blood , precursor cell , pathology , in vitro , biology , immunology , medicine , biochemistry , microbiology and biotechnology
Intraperitoneal injections of PWM in rats had no effect on the haemoglobin concentration or leucocyte and lymphocyte counts. A transformation of the lymphocytes of the peripheral blood to large “blast‐like” DNA‐synthesizing cells – as seen in vitro – did not occur. PWM produced a significant increase of the spleen weight, and the spleen follicles and the red pulp showed an increased cellularity with many pyroninophilic large immature lymphocytes. The lymph nodes showed disorganization of the normal structure with an increased number of immature lymphocytes, reticulum cells and plasma cells. The bone marrow and thymus were unaffected.