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THE OCCURRENCE AND SIGNIFICANCE OF ABNORMAL BILE DUCT EPITHELIUM IN CHRONIC AGGRESSIVE HEPATITIS
Author(s) -
Christoffersen Per,
Dietrichson Odd,
Faber Viggo,
Poulsen Hemming
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00283.x
Subject(s) - epithelium , medicine , gastroenterology , hepatitis , anti nuclear antibody , cholangiocyte , pathology , bile duct , primary biliary cirrhosis , antibody , immunology , autoantibody
A material of 57 primary biopsies exhibiting chronic aggressive hepatitis from 57 patients has been selected from a total consecutive liver biopsy material of 3000. The material is divided into two groups: group 1: 21 patients with abnormal biliary epithelium, group 2: 36 patients without abnormal biliary epithelium. No morphological (apart from the atypical epithelium) or biochemical differences between the two groups have been demonstrated. On the other hand the patients in group 1 are older (all over 45 years of age) than in group 2, just as there is a more pronounced excess of women and a more frequently insidious development of the disease. There is significantly higher incidence of organ‐nonspecific antinuclear factors in group 1 than in group 2, whereas mitochondrial antibodies only is found in serum from one patient. None of the available sera from group 1 and from the female patients in group 2 show presence of Australian antigen but in most of the male patients from group 2 precipitating lines are demonstrated. A morphological follow‐up of slightly more than half of the patients shows a significantly more frequent development of cirrhosis in the group with abnormal biliary epithelium.