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IMPAIRMENT OF THE LYMPHOCYTE RESPONSE TO PHYTOHAEMAGGLUTININ IN CHICKENS WITH MAREK'S DISEASE
Author(s) -
Alm Gunnar V.,
Siccardi Frank J.,
Peterson Raymond D. A.
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00275.x
Subject(s) - phytohaemagglutinin , marek's disease , biology , inoculation , spleen , virology , thymidine , lymphocyte , immunology , virus , in vitro , biochemistry
Spleen lymphoid cells obtained from White Leghorn chickens with Marek's disease exhibited a significantly impaired proliferative response to the mitogen phytohaemagglutinin (PHA) as measured by the incorporation of tritiated thymidine. While chickens infected by the intraperitoneal inoculation of infectious blood on the day of hatching still were able to mount a small PHA response, their contact‐infected pen mates completely failed to respond. Lymphoid tumour cells from the gonads of inoculated chickens with Marek's disease were not stimulated by PHA. Rather, a suppressive effect of PHA on these cells was noted.