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RELATION BETWEEN CEASED URINE EXCRETION AND POSTNEPHRECTOMY INCREASE IN RENIN SUBSTRATE
Author(s) -
Bing Jens,
Jørgensen Jørgen
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00265.x
Subject(s) - urine , nephrectomy , medicine , renin–angiotensin system , endocrinology , excretion , substrate (aquarium) , chemistry , kidney , biology , blood pressure , ecology
Vesico‐venous anastomosis or urine‐infusion in rats resulted in a marked increase in renin substrate, which increase, however, on an average was less pronounced than that found in nephrectomized rats. These results do not allow an unambiguous answer to the question of the role of ceased urine excretion in the postnephrectomy increase in renin substrate in rats. Peritoneal dialysis did not affect renin substrate in normal rats, but increased it in uninephrectomized rats and in binephrectomized rats. The post‐binephrectomy increase in substrate was markedly more pronounced when both kidneys were removed simultaneously than when nephrectomy was performed in two steps.