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THE ISO—AND ALLOTRANSPLANTED RAT HEART
Author(s) -
Heron Iver
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1972.tb00263.x
Subject(s) - antibody , infiltration (hvac) , transplantation , pathology , degeneration (medical) , medicine , immunology , physics , thermodynamics
The morphological changes in 18 isografted and 108 allografted hearts have been studied in three inbred strains of rats. Focal cellular infiltrates were occasionally present in isografts in or near areas of infarction, and showed regressive tendency during the weeks after transplantation. Lymphoid cell infiltration in allografts was observed from the third day and increased progressively till a few days before terminal rejection, at which time extensive myocardial degeneration and oedema were the most prominent changes. Electrocardiograms from isografts remained almost unaltered for prolonged periods, while allografts gradually lost voltage of the R‐wave during rejection. Haemagglutinating red cell antibodies and lymphocytotoxic antibodies were regularly produced during rejection in the combinations investigated.