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Haematological Changes After Injection of Endotoxin into Warfarin‐Treated Rabbits
Author(s) -
Haugen Jostein
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1972.tb00183.x
Subject(s) - warfarin sodium , warfarin , medicine , sodium , chemistry , organic chemistry , atrial fibrillation
A comparison was made of haematological changes in warfarin‐sodium‐treated and in untreated rabbits, given daily intravenous injections of endotoxin from Salmonella typhi for 15 days. Two groups received a low endotoxin dose and two groups a higher dose. Total and differential counts made prior to and 1, 4, and 24 hrs after the 2nd, 8th, and 15th endotoxin injection, showed that the considerable changes of the leukocyte count were dominated by fluctuations of the polymorphonuclear cells. Low endotoxin doses resulted in only a slight change in the mononuclear counts. The higher dose resulted in marked changes which did not parallel those of the polymorphonuclear cells. Following the low endotoxin dose no difference was found between warfarin‐sodium‐treated and untreated rabbits. Following the higher dose a difference was indicated with regard to the polymorphonuclear cells; especially for the response recorded 1 hr after each injection. A decrease was found in the volume of packed red cells, which was recorded every other day in the experimental period. The fall was most marked in the warfarin‐sodium‐treated rabbits, the difference being significant for those receiving the higher dose. The erythrocyte sedimentation rate, which was recorded every other day, increased in all rabbits, the increase being significantly higher in the warfarin‐sodium‐treated than in the untreated rabbits— irrespective of the size of the endotoxin dose.