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RABBIT ANTI RAT LYMPHOCYTE SERUM: COMPARISON OF IN VITRO ACTIVITIES AND IN VIVO EFFECT OF THREE DIFFERENT TYPES OF ANTISERA
Author(s) -
Jakobsen Arnt
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1972.tb00138.x
Subject(s) - antiserum , in vitro , in vivo , lymphocyte , immunology , andrology , chemistry , medicine , antibody , biology , biochemistry , microbiology and biotechnology
In vitro lymphocytotoxic characteristics and the effect on skin allograft survival were studied. Antisera raised with 3 injections showed more lymphocytotoxic activity in the IgM fraction than in the IgG fraction. With increasing number of immunizations the IgM/IgG ratio as judged by the in vitro lymphocytotoxic test was reversed. Antisera raised with 3 injections were much more effective than antisera raised with 8 injections in prolonging the survival of skin allografts. The implications of these findings are discussed.