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INFLUENCE OF GLYCOPROTEIN FROM RED CELL MEMBRANES ON THE AGGLUTINATING AND LYMPHOCYTE STIMULATING ACTIVITY OF PHYTOHAEMAGGLUTININ
Author(s) -
Tärnvik A.,
Carlsson J.
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1972.tb00135.x
Subject(s) - phytohaemagglutinin , agglutination (biology) , platelet , red cell , glycoprotein , microbiology and biotechnology , stimulation , red blood cell , lymphocyte , concanavalin a , biology , biochemistry , hemagglutination , chemistry , immunology , antibody , in vitro , endocrinology , medicine
Lymphocytes were incubated in the presence of each of two phytohaemagglutinin preparations. One of these preparations (H‐PHAP) agglutinated red cells and a mixture of leucocytes and platelets. The other preparation (L‐PHAP) agglutinated leucocytes‐platelets but not red cells. A soluble glycoprotein from red cell membranes markedly inhibited the H‐PHAP‐induced lymphocyte stimulation, but inhibited the L‐PHAP‐induced stimulation slightly or not at all. The glycoprotein inhibited the H‐PHAP‐induced agglutination of red cells and leucocytes‐platelets, but did not inhibit the L‐PHAP‐induced agglutination of leucocytes‐platelets.