Premium
SUPPRESSION OF CARDIAC ALLOGRAFT REJECTION IN ADULT RATS BY PRETREATMENT WITH BONE MARROW CELLS
Author(s) -
Heron Iver
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1972.tb00128.x
Subject(s) - bone marrow , spleen , graft vs host reaction , histocompatibility , immune system , medicine , transplantation , immunology , major histocompatibility complex , bone marrow transplantation , antigen , human leukocyte antigen
Rat hearts were transplanted across major histocompatibility loci in two donor‐recipient combinations. A pronounced and specific suppression of rejection was obtained when recipients were treated with one injection of bone marrow cells 7 days prior to allografting. Histological signs of immune reactions in the grafts were found and some rats produced circulating alloantibodies. Skin grafts were rejected in the one combination but were accepted in the other, when applied to recipients with well tolerated hearts of the same genotype. Normal response of recipient spleen cells in GVHR was obtained, and parabiotic union between recipient with functioning grafts and normal unmodified rats did not effect function of the transplants. The suppressive effect of marrow pretreatment could not be transferred with serum taken from rats at the time of transplantation. The possible mechanisms are discussed.