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THE FATE OF HETEROLOGOUS SPECIFIC AND NON‐SPECIFIC ANTILYMPHOCYTE GLOBULINS IN PLASMA AND TISSUES STUDIED BY A PAIRED‐LABEL TECHNIQUE
Author(s) -
Ranløv Poul,
Rossing Niels,
Hardt Finn
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1972.tb00126.x
Subject(s) - avidity , spleen , heterologous , globulin , chemistry , distribution (mathematics) , immunology , clearance , medicine , endocrinology , antibody , biology , biochemistry , mathematics , mathematical analysis , urology , gene
The elimination and tissue distribution of different batches of rabbit antimurine antilymphocyte globulin and antihuman antilymphocyte globulin were studied by means of a paired‐label technique after injection into mice. The identical over‐all clearance rates of antimurine ALG and control rabbit IgG judged by whole‐body count compared with a slightly lower plasma level of ALG indicated an increased binding of the injected́ ALG to tissues. The plasma deficit of ALG was balanced by a higher uptake in the spleen, liver and kidney, but not in the thymus. In particular, the spleen was found to exhibit a much higher avidity for ALG than for normal IgG, while the actual elimination rates for the two globulins were the same for spleen, other tissues and plasma. The interpretation follows that no accumulation of “fixed” ALG occurred within lymphoid organs, which would have been expected if the “blindfolding” theory of the immunosuppressive effect of ALG is correct. This difference in avidity was roughly correlated to the specificity of the ALG preparation used.