Premium
Localization and Properties of an Acid‐Solubl'e Muscle Antigen Reacting with Antibodies in Myasthenia Gravis Sera
Author(s) -
Aarli J. A.
Publication year - 1972
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1972.tb00060.x
Subject(s) - myasthenia gravis , antigen , antibody , chemistry , skeletal muscle , epitope , immunology , microbiology and biotechnology , biochemistry , medicine , biology , endocrinology
Sera from patients with myasthenia gravis contain antibodies to a citric acid extractable antigen present in heart and skeletal muscle. This antigen is located in the sarcolemmal/subsarcolemmal region of the muscle fibres. The antigen is resistant to pH changes between 2 and 10, but is inactivated by treatment at 56° C for 60 min or at 70° C for 30 min. The antigenic determinant is of protein nature.