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TRANSFORMATION OF RABBIT BLOOD LEUCOCYTES WITH A BOVINE ENCEPHALITOGEN—TEMPORAL PATTERN OF REACTIVITY
Author(s) -
Bergstrand Håkan,
KäLién Bengt
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb03811.x
Subject(s) - antigen , transformation (genetics) , in vitro , cytotoxic t cell , peripheral blood , immunology , thymidine , multiple sclerosis , lymphatic system , biology , chemistry , biochemistry , gene
Peripheral blood leucocytes from rabbits immunized with encephalitogenic antigen of bovine origin transform in vitro under the influence of the antigen. Transformation was registered as incorporation of tritiated thymidine. A closer analysis showed that lymphoid cells which transform are present in the circulation mainly before the debut of the disease. Similar findings have previously been made on cytotoxic lymphoid cells. A possible explanation is that “sensitized” lymphocytes capable of reaction with the antigen are withdrawn from the circulation at the attack on the central nervous sysem. The implications of these findings for the understanding of similar phenomena at multiple sclerosis are briefly discussed.