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STUDIES ON ANTIBODY‐CONTAINING CELLS IN LYMPH NODES AND THE LYMPH OF RABBITS IMMUNIZED WITH HUMAN IMMUNOGLOBULIN G ACCORDING TO VARIOUS SCHEDULES
Author(s) -
Nilsson Olle
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb03807.x
Subject(s) - thoracic duct , lymph , lymph node , lymph node stromal cell , immune system , antibody , lymphatic system , antigen , pathology , immunology , population , biology , efferent ducts , medicine , epididymis , botany , environmental health , sperm
The results of the present study agree with the view that antibody‐synthesizing lymphoid cells spreading along the lymph route take part in the dissemination of the immune response. At an immune response with a more localized antigenic stimulation of the lymphoid tissue, antibody‐containing cells were demonstrable in cell populations from the efferent lymph of the regional lymph node, but never in the thoracic duct lymph. However, such cells were found in the thoracic duct lymph at an immune response with a more generalized antigenic stimulation of the lymphoid tissue contributing to the thoracic duct cell population. The difference in content of antibody‐containing cells in the thoracic duct lymph at the studied immune responses is discussed. A de novo antibody synthesis of antibodies in vitro was conclusively proved in cultures of cell populations from the efferent lymph vessel and the thoracic duct.