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THE HERPES SIMPLEX VIRUS ENCEPHALITIS IN MICE AT DIFFERENT ENVIRONMENTAL TEMPERATURES
Author(s) -
Lycke E.,
Hermodsson S.,
Kristensson K.,
Roos B.E.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb03801.x
Subject(s) - interferon , herpes simplex virus , virus , life span , encephalitis , monoamine neurotransmitter , pathological , dopamine , metabolism , biology , virology , chemistry , medicine , endocrinology , serotonin , receptor , evolutionary biology
Mice inoculated intracerebrally with herpes simplex virus were kept at different environmental temperatures. The life‐span, symptomatology, synthesis of infective virus, interferon and monoamines of the brains as well as the histopathological picture were studied. Increased life‐span and increased numbers of survivors were observed when mice were incubated at temperatures higher than the ordinary room‐temperature. At the higher temperatures the pathological rise in dopamine synthesis observed in mice at room‐temperature almost disappeared and the incidence of excited animals was markedly reduced. The development of neuronal degenerations and pathological vascular permeability was inhibited in mice incubated at 34d̀ in comparison to these conditions in mice kept at 22d̀, whereas no effect on the inflammatory cell response was demonstrable. These effects of the higher environmental temperature were probably not mediated by increased production of interferon. Although it is probable that the symptomatology modified by increased temperature was influenced by changes in metabolism of brain monoamines, the life‐saving result of increasing the environmental temperature seemed dependent upon inhibition of formation of infective virus and of spread of the infection.