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LIPOGRANULOMAS IN HUMAN LIVER BIOPSIES WITH FATTY CHANGE
Author(s) -
Christoffersen Per,
Brændstrup Otto,
Juhl Erik,
Poulsen Hemming
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb03323.x
Subject(s) - steatosis , fatty liver , cirrhosis , parenchyma , pathology , fibrosis , connective tissue , biopsy , liver parenchyma , percutaneous biopsy , medicine , disease
The material comprises 67 percutaneous liver biopsies all with fatty change as the chief morphological diagnosis. Among others biopsies with cirrhosis and Mallory bodies have been excluded. Lipogranulomas have been found in 43 out of 67 biopsies. A description of lipogranulomas is given, and three types are described according to size and age. Steatosis is a conditio sine qua non for the development of lipogranulomas. Biopsies with lipogranulomas show higher histologic activity (lytic liver cell necrosis, acidophilic bodies and rnesenchymal reaction) and more parenchymal fibrosis than biopsies without. The patients with lipogranulomas have higher S. G. O. T. values. Whereas lipogranulomas type 1 and 2 can disappear without sequelae there is good reason to believe that lipogranulomas type 3 may give rise to development of connective tissue in the parenchyma.