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INHIBITORY EFFECT OF DEAE‐DEXTRAN ON TUMOUR GROWTH
Author(s) -
Thorling E. B.,
Larsen B.,
Nielsen H.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb03316.x
Subject(s) - dextran , chemistry , cell , biophysics , ascites , degree (music) , body weight , biochemistry , inhibitory postsynaptic potential , pharmacology , biology , medicine , endocrinology , physics , acoustics
The effect of different DEAE‐dextran derivatives on the surface charge of tumour cells has been investigated. The DEAE‐dextran varied in molecular weight and charge density (degree of substitution with diethyl‐amino‐ethyl groups). It was shown that the binding to the tumour cell surface and the ability to neutralize the negative charge of the cell surface was dependent upon the molecular weight and the charge density. Higher molecular weight and higher degree of substitution gave a stronger binding. The toxicity of the various compounds in mice and amoebae was correlated to the cell surface affinity. The biological effect of the different drugs was investigated in the C3H mice using the transplantable ascites tumour JBI which is a plasmocytoma. The DEAE dextran has an inhibitory effect on the growth of transplanted tumours. This effect was greatest for the compound with the highest molecular weight (2 mill.) and the highest degree of substitution (50 per cent), and was negligible for a compound with molecular weight of 64, 000 and 13 per cent substitution.