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DELAYED HYPERSENSITIVITY IN THE GUINEA PIG IMMUNIZED WITH KILLED TUBERCLE BACILLI IN ADJUVANT
Author(s) -
Kostiala Anja A. I.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb02155.x
Subject(s) - tubercle , bacilli , adjuvant , guinea pig , sensitization , tuberculin , microbiology and biotechnology , delayed hypersensitivity , immunology , medicine , tuberculosis , biology , antigen , pathology , bacteria , genetics
Guinea pigs were immunized with 2.4 mg of killed tubercle bacilli in adjuvant. The effect of Tuberculin Purified Protein Derivative (PPD) concentration on peritoneal cell migration was studied at various times from 7 days to 6 months after sensitization. At 7 days migration was inhibited significantly in the presence of 25 γ PPD/ml but not in the presence of 0.8 γ PPD/ml. At 28 days migration was inhibited highly significantly also with the lower dose. Later after sensitization inhibition was even stronger, at 6 months 0.01 γPPD/ml was also inhibitory.