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DELAYED HYPERSENSITIVITY IN THE GUINEA PIG IMMUNIZED WITH KILLED TUBERCLE BACILLI IN ADJUVANT
Author(s) -
Kostiala Anja A. I.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb02154.x
Subject(s) - tuberculin , tubercle , sensitization , guinea pig , adjuvant , bacilli , antibody , delayed hypersensitivity , immunology , purified protein derivative , medicine , antibody response , microbiology and biotechnology , antigen , tuberculosis , biology , pathology , bacteria , genetics
Guinea pigs were immunized with 2.4 mg of killed tubercle bacilli in adjuvant. From 4 days to one year after sensitization Tuberculin Purified Protein Derivative (PPD) was used to test migration inhibition (25 γ/ml), skin reactivity (10 γ) and antibodies. Delayed 24 hours skin reactions became positive slightly earlier than migration inhibition, hemag‐glutinating antibody and 4 hour skin reactivity. Migration inhibition was very strong 4 and 6 months and one year after sensitization, when the animals also had strong 4 and 24 hour skin reactions and hemolysing antibody.