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THE FORMATION OF ANTIBODIES TO ENDOTOXIN IN WARFARIN‐TREATED RABBITS
Author(s) -
Haugen Jostein
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb02148.x
Subject(s) - antibody , warfarin , hemolysis , coagulation , agglutination (biology) , chemistry , immunology , medicine , atrial fibrillation
Warfarin‐treated and untreated rabbits were immunized by a series of daily injections of Salmonella typhi endotoxin. The sera were tested by bacterial agglutination, indirect hemag‐glutination, indirect hemolysis and precipitation. Analysis of variance showed no difference in the quantity of antibodies formed in warfarin‐treated and untreated rabbits. The antibodies were shown to be exclusively gammaM‐globulins. It is concluded that a constant low coagulation activity, such as that achieved by warfarin treatment, is of no consequence to antibody formation, provided the endotoxin is intravenously administered. This may indicate that the endotoxin‐induced alterations of coagulability do not affect any phase of antibody formation. No correlation seemed to exist between the antibody levels and the pyrogenic response, as measured in the same rabbits.