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A METHOD FOR THE DETERMINATION OF TRANSPLACENTAL TRANSMISSION OF DRUGS
Author(s) -
Andersen Jørgen Bent,
Pedersen Christian Braiie
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb02146.x
Subject(s) - transplacental , kanamycin , fetus , pregnancy , drug , medicine , physiology , placenta , chemistry , pharmacology , biology , antibiotics , biochemistry , genetics
1. A practical laboratory method for the estimation of the kinetics of the drug distribution between mother and foetus is prepared. The method is also suitable with a view to following the kinetics of the drug in the foetus in a period after the maternal organism essentially has freed itself on the drug. The practicability of the method is demonstrated in model experiments using pregnant Guinea‐pigs, treated with Kanamycin. 2. Kanamycin enters the foetal circulation relatively fast but it takes roughly 1 1/2 hours to reach half equilibrium, and roughly 6 hours before practically full equilibrium is reached. Equilibrium levels in foetus serum run at about 7 per cent of that of the maternal serum, unaffected by relatively large variations in dosage levels. Following the cessation of meditation, the mothers eliminate Kanamycin quickly, but the clearance from the foetus is relatively slow. There seems to be some indication that the foetal kidney excretes Kanamycin ‐ but apparently this is only a secondary mechanism in the handling of the drug which entered the foetus. 3. The findings provide a better insight into the apparent difficulties involved if the Corti organs of the foetus are to be affected, even though the mother during pregnancy was subjected to prolonged, multiple administration of very large Kanamycin doses.